Tumor Necrosis Factor (TNF) - Associated Periodic Syndrome (aka Familial Hibernian Fever)
TNF-associated Autoinflammatory Diseases, Protein Folding
Autosomal dominant. Spontaneous mutations, with some familial groups. 
Affects all races. Second most common inherited SAID (after FMF). 
Age of onset:
Most first attacks occur by 3 years of age, and almost all begin by 20 years of age. A few have symptoms start later in life. 
Migrating rash with deep pain under the areas with the rash. Severe pain follows the rash path from the trunk outwards to the limbs. 
Uncommon–not believed to be caused by TRAPS. 
Common, including pleurisy. 
Abdominal pain, peritonitis, diarrhea, and constipation with flares. Splenomegaly. 
Splenomegaly is common; some have lymphadeopathy. 
Joints bones muscles cartilage:
Intermittent or chronic arthritis in the large joints with muscle pain and swelling is common. 
Henoch-Schönlein purpura (HSP), lymphocytic vasculitis. 
10-20% occurrence. Higher risk with a cysteine mutation. 
High: ESR, CRP, SAA. Polymorphonuclear neutrophils (PMNs), polyclonalgammopathy, leukocytosis.  Elevated serum IgD levels10% to 13% of patients with TRAPS (elevated in some with other autoinflammatory diseases too, such as HIDS, MA, FMF, PFAPA) 
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Federici, S., Caorsi, R., & Gattorno, M. (2012). The autoinflammatory diseases. Swiss medical weekly, 142, 0.
Our Autoinflammatory Alliance website TRAPS Syndrome page.
Find periodic fever syndrome panels, which test for TRAPS and syndromes with similar symptoms at the same time, at the Genetic Testing Registry (GTR).