Familial Psoriasis (PSORS2) – aka CARD14-Mediated Pustular Psoriasis

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Acronym:
CAMPS/PSORS2

SAID group:
Pyogenic Diseases

Gene:
CARD14

Inheritance:
Autosomal dominant. Spontaneous mutations, and some familial groups. [23]

Ethnicity:
Most with European or Asian ancestry. Known patients in US, EU, Canada (Newfoundland), Haiti, and Taiwan. [23]

Frequency:
Unknown, but rare.

Timing of symptoms:
Continuous. Chronic pustular or plaque psoriasis triggered by inflammatory stimuli. Some cases with psoriatic arthritis. [23] [24]

Age of onset:
Variable age of onset from infancy or childhood to adulthood with pustular psoriasis. [23] [24]

Skin cutaneous:
Generalized pustular psoriasis (that can be severe), and/or plaque psoriasis. Sometimes nails are affected with psoriasis. [23] [24]

Neurologic:
Not seen. [23] [24]

Auditory:
Not seen. [23] [24]

Ophthalamic:
Not seen. [23] [24]

Cardiopulmonary:
Not seen. [23] [24]

Abdominal:
Not seen. [23] [24]

Lymphatic:
Not seen. [23] [24]

Joints bones muscles cartilage:
Intermittent joint pain, psoriatic arthritis. 30% of affected patients in one European family with PSORS2 also had psoriatic arthritis. [24]

Vasculitis:
Not seen. [23] [24]

Amyloidosis:
Not seen. [23] [24]

Abnormal labs:
Mildly elevated WBC. CRP and ESR are rarely elevated – and only during flares of symptoms. [56]

Search Keywords:
Familial Psoriasis PSORS2, CARD14-Mediated Pustular Psoriasis, CAMPS, Chronic pustular, pustular psoriasis, plaque psoriasis, triggered, psoriatic arthritis, nails, arthritis, psoriasis, pyogenic, nail psoriasis, nail pustules, nail sores, fingernail sores, fingernail psoriasis, fingernail pustules.


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Photo credit:

Cohen, Bernard Pustular psoriasis on an 8 yr. old child. Uploaded 11/25/2006. http://dermatlas.med.jhmi.edu/image/pustularpsoriasis1_061124

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