Familial Psoriasis (PSORS2) – aka CARD14-Mediated Pustular Psoriasis
Autosomal dominant. Spontaneous mutations, and some familial groups. 
Most with European or Asian ancestry. Known patients in US, EU, Canada (Newfoundland), Haiti, and Taiwan. 
Unknown, but rare.
Joints bones muscles cartilage:
Intermittent joint pain, psoriatic arthritis. 30% of affected patients in one European family with PSORS2 also had psoriatic arthritis. 
Mildly elevated WBC. CRP and ESR are rarely elevated – and only during flares of symptoms. 
Familial Psoriasis PSORS2, CARD14-Mediated Pustular Psoriasis, CAMPS, Chronic pustular, pustular psoriasis, plaque psoriasis, triggered, psoriatic arthritis, nails, arthritis, psoriasis, pyogenic, nail psoriasis, nail pustules, nail sores, fingernail sores, fingernail psoriasis, fingernail pustules.
Cohen, Bernard Pustular psoriasis on an 8 yr. old child. Uploaded 11/25/2006. http://dermatlas.med.jhmi.edu/image/pustularpsoriasis1_061124